Microbial Cell Line Development
MABION’s Microbial Upstream Development team has extensive experience in establishing, optimizing and characterizing high cell density Escherichia coli fed-batch processes. For E. coli suitable expression vectors and host strains are available and the microbial cGMP Cell Banking services are embedded in the development group. The overall focus is to develop high yielding cell lines and processes that are robust and scalable, with high productivity, regulatory friendly media.
E. coli cell line development:
• High efficient expression vectors
• Custom cloning
• Host strains custom selection
• Customer expression system possible
• Typical yields – several dozen grams of cells per liter